Anti-Human RAGE Recombinant Antibody (XT-M4) (CAT#: TAB-293CT)
Recombinant monoclonal antibody XT-M4 specifically binds to RAGE and neutralizes RAGE-associated activities. This antibody can be potentially used for treating RAGE-related disease.
Specific Inquiry
PK
![Figure 1 Radioactive equivalent concentrations and total radioactivity, as percentage of administered dose (% dose) of [125I]anti-RAGE Ab in serum, lung and spleen of RAGE-/- and wild-type (129S5) mice following a single 5 mg/kg IV dose.](https://img.creativebiolabs.net/productimages/TAB-293CT-1.png)
Figure 1 Radioactive equivalent concentrations and total radioactivity, as percentage of administered dose (% dose) of [125I]anti-RAGE Ab in serum, lung and spleen of RAGE-/- and wild-type (129S5) mice following a single 5 mg/kg IV dose.
Serum and tissue RE concentrations were monitored by gamma-counting up to ∼5 mo (132 days) in RAGE-/- (open circles) and wild-type (wt) 129S5 (open triangle) mice. The insert in shows serum RE concentrations up to day 9 post-dose. Data show mean ± SD values, with n = 6 per time point. Individual animal concentration values that were less than the limit of quantitation were treated as zero for calculations of the mean and the standard deviation.
Vugmeyster, Y., DeFranco, D., Pittman, D. D., & Xu, X. (2010, September). Pharmacokinetics and lung distribution of a humanized anti-RAGE antibody in wild-type and RAGE-/-mice. In MAbs (Vol. 2, No. 5, pp. 571-575). Taylor & Francis.
Specifications
- Immunogen
- Human RAGE-Fc
- Host Species
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Species Reactivity
- Human, mouse
- Clone
- XT-M4
- Applications
- WB, ELISA, Neut, PK
- Related Disease
- RAGE-related disease
Applications
- Application Notes
- The RAGE antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Neutralization, Pharmacokinetic.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Customer Reviews and Q&As
Customer Review
Q&As
Versatile Research Tool
XT-M4 has become a cornerstone in our lab's study of inflammatory pathways. Its specificity and high sensitivity to RAGE offer us consistent results across ELISA and Western Blot assays. We are particularly impressed by its batch-to-batch consistency, which greatly supports our longitudinal studies.
Great for Chronic Disease Research
As part of a diabetes inflammation project, XT-M4 has provided accurate insights. Its interaction with RAGE-a critical player in insulin resistance-sheds light on inflammation management. The antibody's robust production processes mean we can depend on its consistency and clarity in results.
Exeptional ELISA Performance
This antibody demonstrates superior performance in ELISA assays, with strong binding to recombinant human RAGE protein. The assays are more reliable, giving us the confidence needed for high-stakes projects. Its animal-free production is a bonus for sustainability-focused labs.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-293CT, RRID: AB_3111903)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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